Association analysis of 94 candidate genes and schizophrenia-related endophenotypes.

doi:10.1371/journal.pone.0029630

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Article

Association analysis of 94 candidate genes and schizophrenia-related endophenotypes.

PloS one - 1 Jan 2012

Greenwood Tiffany A, Light Gregory A, Swerdlow Neal R, Radant Allen D, Braff David L

Abstract excerpt

While it is clear that schizophrenia is highly heritable, the genetic basis of this heritability is complex. Human genetic, brain imaging, and model organism studies have met with only modest gains. A complementary research tactic is to evaluate the genetic substrates of quantitative endophenotypes with demonstrated deficits in schizophrenia patients. We used an Illumina custom 1,536-SNP array to interrogate 94...

Topics

Adolescent
Adult
Aged
Black People
Case-Control Studies
Endophenotypes
Female
Gene Regulatory Networks
Genetic Association Studies
Genetic Predisposition to Disease
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Schizophrenia

Signal Transduction

White People

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 22253750
DOI: 10.1371/journal.pone.0029630
PMCID: PMC3258248

Genes

ERBB4
NRG1

Provenance

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