Article
Selecting additional tag SNPs for tolerating missing data in genotyping.
BMC bioinformatics - 1 Nov 2005
Huang Yao-Ting, Zhang Kui, Chen Ting, Chao Kun-Mao
Abstract excerpt
BACKGROUND: Recent studies have shown that the patterns of linkage disequilibrium observed in human populations have a block-like structure, and a small subset of SNPs (called tag SNPs) is sufficient to distinguish each pair of haplotype patterns in the block. In reality, some tag SNPs may be missing, and we may fail to distinguish two distinct haplotypes due to the ambiguity caused by missing data. RESULTS: We...
Topics
- Algorithms
- Chromosome Mapping
- Computational Biology
- Computer Simulation
- DNA Mutational Analysis
- Data Interpretation, Statistical
- Databases, Genetic
- Gene Frequency
- Genetic Markers
- Genetic Predisposition to Disease
- Genome, Human
- Genotype
- Haplotypes
- Humans