Article
A model of higher accuracy for the individual haplotyping problem based on weighted SNP fragments and genotype with errors.
Bioinformatics (Oxford, England) - 1 Jul 2008
Xie Minzhu, Wang Jianxin, Chen Jianer
Abstract excerpt
MOTIVATION: In genetic studies of complex diseases, haplotypes provide more information than genotypes. However, haplotyping is much more difficult than genotyping using biological techniques. Therefore effective computational techniques have been in demand. The individual haplotyping problem is the computational problem of inducing a pair of haplotypes from an individual's aligned SNP fragments. Based on various...
Topics
- Base Sequence
- Chromosome Mapping
- Computer Simulation
- Genetic Linkage
- Genotype
- Haplotypes
- Models, Genetic
- Molecular Sequence Data
- Polymorphism, Single Nucleotide
- Reproducibility of Results
- Sensitivity and Specificity