Article
Cyclin D1 gene (CCND1) polymorphism and the risk of squamous cell carcinoma of the larynx.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery - 1 Jan 2006
Rydzanicz Malgorzata, Golusinski Pawel, Mielcarek-Kuchta Daniela, Golusinski Wojciech, Szyfter Krzysztof
Abstract excerpt
Cyclin D1 is one of the key proteins involved in cell cycle control, and it is believed that its overexpression may be connected with tumorigenesis. A reason for cyclin D1 deregulation may be connected to a common G870A polymorphism at codon 242 in exon 4 of the CCND1 gene. This single nucleotide substitution, localized in the conserved splice donor site between exon 4 and the intron 4 boundary, might modulate...
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