Article
Significance of cyclin D1 polymorphisms in patients with head and neck cancer.
The International journal of biological markers - 23 Apr 2013
Sabir Maimoona, Baig Ruqia Mehmood, Mahjabeen Ishrat, Kayani Mahmood Akhtar
Abstract excerpt
Cyclin D1 plays a key role in cell cycle control, particularly in the transition from G1 to S phase, regulated by cyclin-dependent kinases. The objective of the present study was to screen the cyclin D1 gene (CCND1) for polymorphisms in patients with head and neck cancer (HNC). Genomic DNA was isolated from blood samples of 380 HNC patients and 350 controls. In a hospital-based case-control study using the...
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