Article
Cyclin D1 A870G polymorphism and amplification in laryngeal squamous cell carcinoma: implications of tumor localization and tobacco exposure.
Cancer detection and prevention - 1 Jan 2004
Monteiro Eurico, Varzim Graça, Pires Ana M, Teixeira Manuel, Lopes Carlos
Abstract excerpt
Altered Cyclin D1 activity, due to gene amplification and/or protein overexpression, is related to the development of several human cancers, including head and neck SCC. This study investigated the relationship between CCND1 A870G gene polymorphism and amplification with the development and progression of laryngeal SCC, considering the implications of tumor localization and tobacco exposure. The study population...
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