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Article

Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization.

Cell cycle (Georgetown, Tex.) - 1 Nov 2005

Gerlitz Gabi, Darhin Enbal, Giorgio Giovanna, Franco Brunella, Reiner Orly

Abstract excerpt

The presence of a conserved protein motif usually implies common functional features. Here, we focused on the LisH (LIS1 homology) domain, which is found in multiple proteins, and have focused on three involved in human genetic diseases; LIS1, Transducin beta-like 1X (TBL1) and Oral-facial-digital type 1 (OFD1). The recently solved structure of the LisH domain in the N-terminal region of LIS1 depicted it as a...

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PMID: 16258276
DOI: 10.4161/cc.4.11.2151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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