Article
Dimerization of elongator protein 1 is essential for Elongator complex assembly.
Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2015
Xu Huisha, Lin Zhijie, Li Fengzhi, Diao Wentao, Dong Chunming, Zhou Hao, Xie Xingqiao, Wang Zheng, Shen Yuequan, Long Jiafu
Abstract excerpt
The evolutionarily conserved Elongator complex, which is composed of six subunits elongator protein 1 (Elp1 to -6), plays vital roles in gene regulation. The molecular hallmark of familial dysautonomia (FD) is the splicing mutation of Elp1 [also known as IκB kinase complex-associated protein (IKAP)] in the nervous system that is believed to be the primary cause of the devastating symptoms of this disease. Here,...
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