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Article

Essential Role of hIST1 in Cytokinesis

7 Jan 2009

Abstract excerpt

The last steps of multivesicular body (MVB) formation, human immunodeficiency virus (HIV)-1 budding and cytokinesis require a functional endosomal sorting complex required for transport (ESCRT) machinery to facilitate topologically equivalent membrane fission events. Increased sodium tolerance (IST) 1, a new positive modulator of the ESCRT pathway, has been described recently, but an essential function of this...

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PMID: 19129480
DOI: 10.1091/mbc.e08-05-0474

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