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Article

Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Apr 2011

Ellison David W, Kocak Mehmet, Dalton James, Megahed Hisham, Lusher Meryl E, Ryan Sarra L, Zhao Wei, Nicholson Sarah Leigh, Taylor Roger E, Bailey Simon, Clifford Steven C

Abstract excerpt

PURPOSE: Medulloblastomas are heterogeneous and include relatively good-prognosis tumors characterized by Wnt pathway activation, as well as those that cannot be successfully treated with conventional therapy. Developing a practical therapeutic stratification that allows accurate identification of disease risk offers the potential to individualize adjuvant therapy and to minimize long-term adverse effects in a...

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Source

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Identifiers

PMID: 20921458
DOI: 10.1200/JCO.2010.30.2810
PMCID: PMC3525837

Genes

MYC
CTNNB1
MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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