Article
A CTNNB1-altered medulloblastoma shows the immunophenotypic, DNA methylation and transcriptomic profiles of SHH-activated, and not WNT-activated, medulloblastoma.
Neuropathology and applied neurobiology - 1 Aug 2022
Chiang Jason, Moreira Daniel C, Pytel Nicholas J, Liu Yen-Chun, Blackburn Patrick R, Shi Zonggao, Cardenas Maria, Wheeler David A, Furtado Larissa V
Abstract excerpt
Recent advancements in molecular characterisation have identified four principal molecular groups of medulloblastoma: WNT, SHH, group 3 and group 4. Each has its characteristic clinical features, signature genetic alterations and distinct DNA methylome profiles. Thus far, CTNNB1 mutations have been considered pathognomonic of WNT-activated medulloblastoma. Furthermore, it has been shown that CTNNB1 mutations...
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