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Article

Evolving Biology and Therapy of WNT-Activated Medulloblastoma.

Journal of the National Comprehensive Cancer Network : JNCCN - 18 Sept 2025

Mikkelsen Margit K, Pinto Soniya N, Chiang Jason, Shimony Nir, Gajjar Amar

Abstract excerpt

WNT-activated medulloblastoma is one of the 4 molecularly defined subgroups of medulloblastoma and is characterized by distinct molecular, biological, and clinical features. These tumors originate from progenitor cells in the lower rhombic lip, leading to a characteristic anatomical location: midline, often involving the fourth ventricle and dorsal brainstem. This distinct location can help differentiate...

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Identifiers

PMID: 40967259
DOI: 10.6004/jnccn.2025.7061

Genes

APC
CTNNB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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