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Article

Molecular stratification of medulloblastoma: comparison of histological and genetic methods to detect <scp>Wnt</scp> activated tumours

4 Jun 2014

Abstract excerpt

AIMS: Wnt activation in medulloblastomas is associated with good outcome. Upfront testing and risk-adapted stratification of patients will be done in future clinical studies. In a cohort of 186 paediatric medulloblastomas our aim was to identify the optimal methods in standard clinical practice to detect this subgroup. METHODS: Nuclear accumulation of β-catenin was analysed by immunohistochemistry (IHC). DNA of...

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Share to Glioma Diagnosis and Treatment
Share to Hedgehog Signaling Pathway Studies
Share to Wnt/β-catenin signaling in development and cancer

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PMID: 24894640
DOI: 10.1111/nan.12161

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