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Integrating Molecular Subclassification of Medulloblastomas into Routine Clinical Practice: A Simplified Approach

29 Jul 2015

Abstract excerpt

Medulloblastoma (MB) is composed of four molecular subgroups viz. WNT, SHH, groups 3 and 4, identified using various high-throughput methods. Translation of this molecular data into pathologist-friendly techniques that would be applicable in laboratories all over the world is a major challenge. Ninety-two MBs were analyzed using a panel of 10 IHC markers, real-time PCR for mRNA and miRNA expression, and FISH for...

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PMID: 26222673
DOI: 10.1111/bpa.12293

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