Article
Immunohistochemical Surrogates for Molecular Stratification in Medulloblastoma.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Sept 2023
Chinnam Dheeraj, Saraswati Aastha, Jogunoori Swathi, Verma Aanchal, Kiran Tanvi, Salunke Pravin, Gupta Nalini, Kumar Narendra, Madan Renu, Radotra Bishan Dass, Gupta Kirti
Abstract excerpt
BACKGROUND: The WHO classification of central nervous system neoplasms (2016) recognized 4 histologic variants and genetically defined molecular subgroups within medulloblastoma (MB). Further, in the 2021 classification, new subtypes have been provisionally added within the existing subgroups reflecting the biological diversity. YAP1, GAB1, and β-catenin were conventionally accepted as surrogate markers to...
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