Clinical relevance of alterations in quantity and quality of plasma DNA in colorectal cancer patients: based on the mutation spectra detected in primary tumors.

Abstract excerpt

BACKGROUND: While circulating plasma DNA (cpDNA) likely originates in tumors, its utility is limited without knowledge of tumor mutations. This study assessed mutational spectra in primary tumors and clarified the utility of quantitative and qualitative cpDNA alterations in colorectal cancer (CRC) patients. MATERIALS AND METHODS: Between 2005 and 2006, 191 surgical colorectal cancer patients at Taipei Veterans...

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