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Article

A genome-wide, end-sequenced 129Sv BAC library resource for targeting vector construction.

Genomics - 1 Dec 2005

Adams David J, Quail Michael A, Cox Tony, van der Weyden Louise, Gorick Barbara D, Su Qin, Chan Wei-in, Davies Rob, Bonfield James K, Law Frances, Humphray Sean, Plumb Bob, Liu Pentao, Rogers Jane, Bradley Allan

Abstract excerpt

The majority of gene-targeting experiments in mice are performed in 129Sv-derived embryonic stem (ES) cell lines, which are generally considered to be more reliable at colonizing the germ line than ES cells derived from other strains. Gene targeting is reliant on homologous recombination of a targeting vector with the host ES cell genome. The efficiency of recombination is affected by many factors, including the...

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Identifiers

PMID: 16257172
DOI: 10.1016/j.ygeno.2005.08.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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