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Article

Altered dopaminergic innervation and amphetamine response in adult Otx2 conditional mutant mice.

Molecular and cellular neurosciences - 1 Feb 2006

Borgkvist Anders, Puelles Eduardo, Carta Manolo, Acampora Dario, Ang Siew-Lan, Wurst Wolfgang, Goiny Michel, Fisone Gilberto, Simeone Antonio, Usiello Alessandro

Abstract excerpt

Here, we have investigated the neurological consequences of restricted inactivation of Otx2 in adult En1(cre/+); Otx2(flox/flox) mice. In agreement with the crucial role of Otx2 in midbrain patterning, the mutants had a substantial reduction in tyrosine hydroxylase containing neurons. Although the reduction in the number of DAergic neurons was comparable between the SNc and the VTA, we found an unexpected...

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PMID: 16256364
DOI: 10.1016/j.mcn.2005.09.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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