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KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival

28 Oct 2005

Abstract excerpt

Mutations in codon D816 of the KIT gene represent a recurrent genetic alteration in acute myeloid leukemia (AML). To clarify the biologic implication of activation loop mutations of the KIT gene, 1940 randomly selected AML patients were analyzed. In total, 33 (1.7%) of 1940 patients were positive for D816 mutations. Of these 33 patients, 8 (24.2%) had a t(8;21), which was significantly higher compared with the...

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PMID: 16254134
DOI: 10.1182/blood-2005-04-1466

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KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survivalPMID 16254134Read ↗

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