Article
AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2.
Leukemia - 1 Sept 2009
Jiao B, Wu C-F, Liang Y, Chen H-M, Xiong S-M, Chen B, Shi J-Y, Wang Y-Y, Wang J-H, Chen Y, Li J-M, Gu L-J, Tang J-Y, Shen Z-X, Gu B-W, Zhao W-L, Chen Z, Chen S-J
Abstract excerpt
AML1-ETO fusion gene is generated from chromosomal translocation t(8;21) mainly in acute myeloid leukemia M2 subtype (AML-M2). Its spliced variant transcript, AML1-ETO9a, rapidly induces leukemia in murine model. To evaluate its clinical significance, AML1-ETO9a expression was assessed in 118 patients with t(8;21) AML-M2, using qualitative and nested quantitative reverse transcriptase (RT)-PCR methods. These...
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