Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myeloid neoplasms with mutated KIT: comparative clinicopathologic analysis of D816 vs. non-D816 variants.

Cancer genetics - 1 Jun 2026

Aqil Barina, Santana-Santos Lucas, Gao Juehua, Kaur Amandeep, Lu Xinyan, Jennings Lawrence J, Abaza Yasmin, Ji Peng, Sukhanova Madina

Abstract excerpt

KIT mutations are recurrent genetic alterations in myeloid neoplasms (MNs), with the D816 hot-spot variant recognized as a poor prognostic marker in acute myeloid leukemia (AML) with RUNX1::RUNX1T1 and as a diagnostic criterion for systemic mastocytosis (SM). In contrast, the clinical and biological relevance of KIT mutations outside codon 816 remains insufficiently characterized. We retrospectively analyzed 40...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RUNX1 gene

Share to Leukemia, Myeloid, Acute

Share to Mastocytosis, Systemic

Share to Mutation

Share to Prognosis

Share to Proto-Oncogene Proteins c-kit

Source

Identifiers

PMID: 42102664
DOI: 10.1016/j.cancergen.2026.04.009

Genes

KIT
RUNX1
RUNX1T1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myeloid neoplasms with mutated KIT: comparative clinicopathologic analysis of D816 vs. non-D816 variants.PMID 42102664Read ↗

KIT D816 mutated/CBF-negative acute myeloid leukemia: a poor-risk subtype associated with systemic mastocytosisSemantic proximity Read ↗

Comprehensive Analysis of Acquired Genetic Variants and Their Prognostic Impact in Systemic MastocytosisSemantic proximity Read ↗

High frequency of concomitant mastocytosis in patients with acute myeloid leukemia exhibiting the transforming KIT mutation D816V.Semantic proximity Read ↗

Kit Mutations: New Insights and Diagnostic Value.Semantic proximity Read ↗

Unresponsive Systemic Mastocytosis in a Young AML With RUNX1::RUNX1T1 Fusion With Rare KIT c.1255_1257delGAC Mutation: A Clinical Deadlock.Semantic proximity Read ↗

Detection of the KITD816V mutation in myelodysplastic and/or myeloproliferative neoplasms and acute myeloid leukemia with myelodysplasia-related changes predicts concurrent systemic mastocytosis.Semantic proximity Read ↗

Utility of KIT Mutations in Myeloid Neoplasms Without Documented Systemic Mastocytosis to Detect Hidden Mast Cells in Bone Marrow.Semantic proximity Read ↗

The prognostic impact of c-KIT mutation in systemic mastocytosis associated with acute myeloid leukaemia patients.Semantic proximity Read ↗

De novo leukemic variant of mast cell leukemia with KIT D816V.Semantic proximity Read ↗

KIT D816V–mutated bone marrow mesenchymal stem cells in indolent systemic mastocytosis are associated with disease progressionSemantic proximity Read ↗

Mast cell disease associated with acute myeloid leukemia: detection of a new c-kit mutation Asp816His.Semantic proximity Read ↗

Variable presence of KITD816V in clonal haematological non-mast cell lineage diseases associated with systemic mastocytosis (SM-AHNMD).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.