Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacogenetic analysis of rosiglitazone-induced hepatosteatosis in new mouse models of type 2 diabetes.

Diabetes - 1 Jun 2005

Pan Huei-Ju, Reifsnyder Peter, Vance Dennis E, Xiao Qiang, Leiter Edward H

Abstract excerpt

Although thiazolidinediones suppress hyperglycemia in diabetic (NON x NZO)F1 males, these mice exhibit unusual sensitivity to drug-induced exacerbation of an underlying hepatosteatosis only rarely experienced in human patients. To establish the pharmacogenetic basis for this sensitivity, a panel of recombinant congenic strains (RCSs) with varying degrees of obesity and diabetes was generated by fixing selected...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fatty Liver
Share to Hypoglycemic Agents
Share to Liver

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Congenic

Share to Pharmacogenetics

Share to Phosphatidylcholines

Share to Rosiglitazone

Share to Thiazolidinediones

Source

Identifiers

PMID: 15919809
DOI: 10.2337/diabetes.54.6.1854

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacogenetic analysis of rosiglitazone-induced hepatosteatosis in new mouse models of type 2 diabetes.PMID 15919809Read ↗

Differential endocrine responses to rosiglitazone therapy in new mouse models of type 2 diabetes.Semantic proximity Read ↗

Pathophysiology and genetics of obesity and diabetes in the New Zealand obese mouse: a model of the human metabolic syndrome.Semantic proximity Read ↗

Differential Levels of Diabetogenic Stress in Two New Mouse Models of Obesity and Type 2 DiabetesSemantic proximity Read ↗

Deconstructing and reconstructing obesity-induced diabetes (diabesity) in mice.Semantic proximity Read ↗

The diabetes-prone NZO/HlLt strain. I. Immunophenotypic comparison to the related NZB/BlNJ and NZW/LacJ strains.Semantic proximity Read ↗

Precision pharmacological reversal of genotype-specific diet-induced metabolic syndrome in mice informed by transcriptional regulationSemantic proximity Read ↗

Diet-dependent obesity and hypercholesterolemia in the New Zealand obese mouse: identification of a quantitative trait locus for elevated serum cholesterol on the distal mouse chromosome 5.Semantic proximity Read ↗

Type 2 diabetes-like hyperglycemia in a backcross model of NZO and SJL mice: characterization of a susceptibility locus on chromosome 4 and its relation with obesity.Semantic proximity Read ↗

Congenic mice demonstrate the presence of QTLs conferring obesity and hypercholesterolemia on chromosome 1 in the TALLYHO mouse.Semantic proximity Read ↗

Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice.Semantic proximity Read ↗

The newly inbred cohen diabetic rat: a nonobese normolipidemic genetic model of diet-induced type 2 diabetes expressing sex differences.Semantic proximity Read ↗

Does rosiglitazone affect adiposity and cardiac function in genetic diabetic mice?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.