Article
Multiple hypothesis testing strategies for genetic case-control association studies.
Statistics in medicine - 30 Sept 2006
Rosenberg Philip S, Che Anney, Chen Bingshu E
Abstract excerpt
The genetic case-control association study of unrelated subjects is a leading method to identify single nucleotide polymorphisms (SNPs) and SNP haplotypes that modulate the risk of complex diseases. Association studies often genotype several SNPs in a number of candidate genes; we propose a two-stage approach to address the inherent statistical multiple comparisons problem. In the first stage, each gene's...
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