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Article

A high-dimensional omnibus test for set-based association analysis.

Briefings in bioinformatics - 25 Jul 2024

Yang Haitao, Wang Xin, Zhang Zechen, Chen Fuzhao, Cao Hongyan, Yan Lina, Gao Xia, Dong Hui, Cui Yuehua

Abstract excerpt

Set-based association analysis is a valuable tool in studying the etiology of complex diseases in genome-wide association studies, as it allows for the joint testing of variants in a region or group. Two common types of single nucleotide polymorphism (SNP)-disease functional models are recognized when evaluating the joint function of a set of SNP: the cumulative weak signal model, in which multiple functional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39288231
DOI: 10.1093/bib/bbae456
PMCID: PMC11407446

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