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Article

Karyotype-specific microRNA signature in chronic lymphocytic leukemia

28 Aug 2009

Abstract excerpt

Chromosomal abnormalities, immunoglobulin heavy chain variable-region (IGHV) gene mutation status, and zeta-associated protein 70 (ZAP-70) expression levels have independent prognostic relevance in chronic lymphocytic leukemia (CLL); however, their concordance is variable. Because deregulation of microRNAs has been linked to disease initiation and progression in CLL, we studied the value of the microRNAs as a...

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PMID: 19717645
DOI: 10.1182/blood-2009-06-229211

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