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Article

SRC-1, a non-receptor type of protein tyrosine kinase, controls the direction of cell and growth cone migration in C. elegans.

Development (Cambridge, England) - 1 Dec 2005

Itoh Bunsho, Hirose Takashi, Takata Nozomu, Nishiwaki Kiyoji, Koga Makoto, Ohshima Yasumi, Okada Masato

Abstract excerpt

Src family tyrosine kinase (SFK) has been implicated in the regulation of cell adhesion and migration during animal development. We show that SRC-1, an ortholog of SFK, plays an essential role in directing cell migration in Caenorhabditis elegans. The mutation in the src-1 gene results in defective distal tip cell (DTC)-directed gonad morphogenesis in an activity-dependent and DTC cell-autonomous manners. In the...

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PMID: 16251208
DOI: 10.1242/dev.02103

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SRC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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