Article
Is spatial distribution of the HIV-1-resistant CCR5Delta32 allele formed by ecological factors?
Journal of physiological anthropology and applied human science - 1 Jul 2005
Balanovsky Oleg, Pocheshkhova Elvira, Pshenichnov Andrey, Solovieva Daria, Kuznetsova Marina, Voronko Olga, Churnosov Michail, Tegako Olga, Atramentova Lubov, Lavryashina Maria, Evseeva Irina, Borinska Svetlana, Boldyreva Margarita, Dubova Nadezhda, Balanovska Elena
Abstract excerpt
It has been proposed that the Delta32 mutation in the chemokine receptor gene, inducing resistance to HIV-1 and, probably, to other virus infections, has undergone selection in historical times. The frequency of this mutant allele has changed rapidly both in time (during the last two millennia) and in space (across Eurasia). We compiled a global database on Delta32 allele frequencies in 300 populations. Nearly 10...
Topics
- Asia
- Databases, Genetic
- Demography
- Emigration and Immigration
- Environment
- Europe
- Gene Frequency
- Genetic Predisposition to Disease
- Genetics, Population
- HIV Infections
- HIV-1
- Humans