Article
Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes.
American journal of human genetics - 1 Jun 1998
Stephens J C, Reich D E, Goldstein D B, Shin H D, Smith M W, Carrington M, Winkler C, Huttley G A, Allikmets R, Schriml L, Gerrard B, Malasky M, Ramos M D, Morlot S, Tzetis M, Oddoux C, di Giovine F S, Nasioulas G, Chandler D, Aseev M, Hanson M, Kalaydjieva L, Glavac D, Gasparini P, Kanavakis E, Claustres M, Kambouris M, Ostrer H, Duff G, Baranov V, Sibul H, Metspalu A, Goldman D, Martin N, Duffy D, Schmidtke J, Estivill X, O'Brien S J, Dean M
Abstract excerpt
The CCR5-Delta32 deletion obliterates the CCR5 chemokine and the human immunodeficiency virus (HIV)-1 coreceptor on lymphoid cells, leading to strong resistance against HIV-1 infection and AIDS. A genotype survey of 4,166 individuals revealed a cline of CCR5-Delta32 allele frequencies of 0%-14% a...
Topics
- Acquired Immunodeficiency Syndrome
- Alleles
- Evolution, Molecular
- Gene Deletion
- Gene Frequency
- Haplotypes
- Humans
- Hybrid Cells
- Immunity, Innate