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Article

Evaluating plague and smallpox as historical selective pressures for the CCR5-Delta 32 HIV-resistance allele.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2003

Galvani Alison P, Slatkin Montgomery

Abstract excerpt

The high frequency, recent origin, and geographic distribution of the CCR5-Delta 32 deletion allele together indicate that it has been intensely selected in Europe. Although the allele confers resistance against HIV-1, HIV has not existed in the human population long enough to account for this se...

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Source

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Identifiers

PMID: 14645720
DOI: 10.1073/pnas.2435085100
PMCID: PMC299980

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14645720-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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