Article
Copper alters the conformation and transcriptional activity of the tumor suppressor protein p53 in human Hep G2 cells.
Experimental biology and medicine (Maywood, N.J.) - 1 Nov 2005
Tassabehji Nadine M, VanLandingham Jacob W, Levenson Cathy W
Abstract excerpt
The tumor suppressor protein p53 plays a role in the molecular response to DNA damage by acting as a DNA-binding transcription factor that regulates specific target genes to arrest the cell cycle, induce repair mechanisms, and initiate apoptotic cell death. To test the effect of copper on the transcriptional activity of p53, Hep G2 cells were transiently transfected with a luciferase reporter gene downstream from...
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