Article
Gene expression profiling in chronic copper overload reveals upregulation of Prnp and App.
Physiological genomics - 15 Dec 2004
Armendariz Angela D, Gonzalez Mauricio, Loguinov Alexander V, Vulpe Christopher D
Abstract excerpt
The level at which copper becomes toxic is not clear. Several studies have indicated that copper causes oxidative stress; however, most have tested very high levels of copper exposure. We currently have only a limited understanding of the protective systems that operate in cells chronically exposed to copper. Additionally, the limits of homeostatic regulation are not known, making it difficult to define the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.