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Article

Three assays show differences in binding of wild-type and mutant p53 to unique gene sequences.

Technology in cancer research & treatment - 1 Dec 2009

Chandrachud Uma, Gal Susannah

Abstract excerpt

Cancer-associated mutations in the p53 gene often change amino acids in the protein's DNA binding domain. We used three different binding assays specifically gel shift, DNA binding scintillation proximity assay and a streptavidin magnetic bead assay to analyze the DNA binding of the tumor suppres...

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Share to Cell Line, Tumor
Share to Cell Nucleus
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

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Share to Transcription, Genetic

Share to Tumor Suppressor Protein p53

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Identifiers

PMID: 19925028
DOI: 10.1177/153303460900800606
PMCID: PMC2917581

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19925028-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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