Article
The quakingviable mutation affects qkI mRNA expression specifically in myelin-producing cells of the nervous system.
Nucleic acids research - 1 Aug 2003
Lu Zifan, Zhang Youyi, Ku Li, Wang Houping, Ahmadian Amir, Feng Yue
Abstract excerpt
The genetic lesion in the quakingviable (qk(v)) mutant mice is a deletion 5' to the qkI gene, resulting in severe hypomyelination. qkI produces several QKI protein isoforms via alternative splicing of the C-terminal coding exons. In the qk(v)/qk(v) brain, immunostaining of QKI proteins is diminished in an isoform-differential manner with undefined mechanisms. We examined the expression of QKI protein isoforms and...
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