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Article

Deletion of the Parkin coregulated gene causes male sterility in the quaking(viable) mouse mutant.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 2004

Lorenzetti Diego, Bishop Colin E, Justice Monica J

Abstract excerpt

Quaking(viable) (qk(v)) is a recessive neurological mouse mutation with severe dysmyelination of the CNS and spermiogenesis failure. The molecular lesion in the qk(v) mutant is a deletion of approximately 1 Mb on mouse chromosome 17 that alters the expression of the qk gene in oligodendrocytes. Complementation analysis between the qk(v) mutation and qk mutant alleles generated through chemical mutagenesis showed...

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Identifiers

PMID: 15148410
DOI: 10.1073/pnas.0401832101
PMCID: PMC420406

Genes

PACRG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of the Parkin coregulated gene causes male sterility in the quaking(viable) mouse mutant.PMID 15148410Read ↗

Defining the breakpoints of the quaking(viable) mouse mutation reveals a duplication from a Parkin intron.Semantic proximity Read ↗

It's a double knock-out! The quaking mouse is a spontaneous deletion of parkin and parkin co-regulated gene (PACRG).Semantic proximity Read ↗

A new ENU-induced allele of mouse quaking causes severe CNS dysmyelination.Semantic proximity Read ↗

Loss of p53 in quaking viable mice leads to Purkinje cell defects and reduced survival.Semantic proximity Read ↗

The quaking gene product necessary in embryogenesis and myelination combines features of RNA binding and signal transduction proteins.Semantic proximity Read ↗

Primary ciliary dyskinesia in mice lacking the novel ciliary protein Pcdp1.Semantic proximity Read ↗

The quaking I-5 protein (QKI-5) has a novel nuclear localization signal and shuttles between the nucleus and the cytoplasm.Semantic proximity Read ↗

Generation and characterisation of a parkin-Pacrg knockout mouse line and a Pacrg knockout mouse lineSemantic proximity Read ↗

Molecular analysis of the PArkin co-regulated gene and association with male infertility.Semantic proximity Read ↗

Chimeric analysis with newly established EGFP/DsRed2-tagged ES cells identify HYDIN as essential for spermiogenesis in mice.Semantic proximity Read ↗

The Drosophila parkin homologue is required for normal mitochondrial dynamics during spermiogenesisSemantic proximity Read ↗

The neurological mouse mutations jittery and hesitant are allelic and map to the region of mouse chromosome 10 homologous to 19p13.3.Semantic proximity Read ↗

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