Article
Loss of p53 in quaking viable mice leads to Purkinje cell defects and reduced survival.
Scientific reports - 1 Jan 2011
Gavino Christina, Richard Stéphane
Abstract excerpt
The qk(v) mutation is a one megabase deletion resulting in abnormal expression of the qkI gene. qk(v) mice exhibit hypomyelination of the central nervous system and display rapid tremors and seizures as adults. The qkI locus on 6q26-27 has also been implicated as a candidate tumor suppressor gene as the qkI locus maps to a region of genetic instability in Glioblastoma Multiforme (GBM), an aggressive brain tumor...
Topics
- Animals
- Base Sequence
- Brain Neoplasms
- DNA Primers
- Genomic Instability
- Glioblastoma
- Immunohistochemistry
- Mice
- Mice, Knockout
- Mice, Quaking
- Mutation
- Polymerase Chain Reaction
- Purkinje Cells
- Survival Analysis
- Tumor Suppressor Protein p53