Article
Molecular characterization of human monoclonal antibodies specific for several HIV proteins: analysis of the VH3 family expression.
Immunology letters - 1 Jan 2000
David D, Goossens D, Desgranges C, Thèze J, Zouali M
Abstract excerpt
We have analyzed the heavy-chain variable (VH) region genes expressed by a panel of human monoclonal antibodies derived from an immunized volunteer, an AIDS patient and seropositive asymptomatic donors, and specific for HIV-1 env, pol and gag gene products. The third complementarity-determining regions show a high complexity with unconventional gene recombination events. Most of the VH genes utilized are also...
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