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Article

Mercury and zinc differentially inhibit shark and human CFTR orthologues: involvement of shark cysteine 102.

American journal of physiology. Cell physiology - 1 Mar 2006

Weber Gerhard J, Mehr Ali Poyan, Sirota Jeffrey C, Aller Stephen G, Decker Sarah E, Dawson David C, Forrest John N

Abstract excerpt

The apical membrane is an important site of mercury toxicity in shark rectal gland tubular cells. We compared the effects of mercury and other thiol-reacting agents on shark CFTR (sCFTR) and human CFTR (hCFTR) chloride channels using two-electrode voltage clamping of cRNA microinjected Xenopus laevis oocytes. Chloride conductance was stimulated by perfusing with 10 microM forskolin (FOR) and 1 mM IBMX, and then...

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Source

Identifiers

PMID: 16236827
DOI: 10.1152/ajpcell.00203.2005

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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