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Article

Functional significance of conserved cysteines in the human organic cation transporter 2.

American journal of physiology. Renal physiology - 15 Jul 2012

Pelis Ryan M, Dangprapai Yodying, Cheng Yaofeng, Zhang Xiaohong, Terpstra Jennifer, Wright Stephen H

Abstract excerpt

The significance of conserved cysteines in the human organic cation transporter 2 (hOCT2), namely the six cysteines in the long extracellular loop (loop cysteines) and C474 in transmembrane helix 11, was examined. Uptake of tetraethylammonium (TEA) and 1-methyl-4-phenypyridinium (MPP) into Chinese hamster ovary cells was stimulated >20-fold by hOCT2 expression. Both cell surface expression and transport activity...

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Identifiers

PMID: 22573376
DOI: 10.1152/ajprenal.00038.2012
PMCID: PMC3404585

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