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Article

Cloning, characterization, and functional expression of a CNP receptor regulating CFTR in the shark rectal gland

1 Feb 1999

Abstract excerpt

In the shark, C-type natriuretic peptide (CNP) is the only cardiac natriuretic hormone identified and is a potent activator of Cl- secretion in the rectal gland, an epithelial organ of this species that contains cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels. We have cloned an ancestral CNP receptor (NPR-B) from the shark rectal gland that has an overall amino acid identity to the human...

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PMID: 9950772
DOI: 10.1152/ajpcell.1999.276.2.c442

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