Article
Inhibition of Na(+)-K(+)-2Cl(-) cotransport by mercury.
The American journal of physiology - 1 Oct 1999
Jacoby S C, Gagnon E, Caron L, Chang J, Isenring P
Abstract excerpt
Mercury alters the function of proteins by reacting with cysteinyl sulfhydryl (SH(-)) groups. The inorganic form (Hg(2+)) is toxic to epithelial tissues and interacts with various transport proteins including the Na(+) pump and Cl(-) channels. In this study, we determined whether the Na(+)-K(+)-Cl(-) cotransporter type 1 (NKCC1), a major ion pathway in secretory tissues, is also affected by mercurial substrates....
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