Article
Impact of trimethoprim-sulfamethoxazole prophylaxis on falciparum malaria infection and disease.
The Journal of infectious diseases - 15 Nov 2005
Thera Mahamadou A, Sehdev Paul S, Coulibaly Drissa, Traore Karim, Garba Mamane N, Cissoko Yacouba, Kone Abdoulaye, Guindo Ando, Dicko Alassane, Beavogui Abdoul H, Djimde Abdoulaye A, Lyke Kirsten E, Diallo Dapa A, Doumbo Ogobara K, Plowe Christopher V
Abstract excerpt
BACKGROUND: Trimethoprim-sulfamethoxazole (TS) prophylaxis is recommended for persons living with human immunodeficiency virus infection and acquired immunodeficiency syndrome in Africa. TS and the antimalarial combination sulfadoxine-pyrimethamine (SP) share mechanisms of action and resistance patterns, and concerns about the impact of TS resistance on SP efficacy have contributed to reluctance to implement TS...
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