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Article

Monitoring antifolate resistance in intermittent preventive therapy for malaria.

Trends in parasitology - 1 Oct 2013

Venkatesan Meera, Alifrangis Michael, Roper Cally, Plowe Christopher V

Abstract excerpt

Mutations in the Plasmodium falciparum genes Pfdhfr and Pfdhps have rendered sulfadoxine-pyrimethamine (SP) ineffective for malaria treatment in most regions of the world. Yet, SP is efficacious as intermittent preventive therapy in pregnant women (IPTp) and infants (IPTi) and as seasonal malaria control in children (SMC). SP-IPTp is being widely implemented in sub-Saharan Africa. SP-IPTi is recommended where the...

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Pyrimethamine
Antimalarials
Drug Combinations
Drug Resistance
Malaria, Falciparum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmodium falciparum

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Identifiers

PMID: 23948432
DOI: 10.1016/j.pt.2013.07.008
PMCID: PMC3810209

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Monitoring antifolate resistance in intermittent preventive therapy for malaria.PMID 23948432Read ↗

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