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Seasonal malaria chemoprevention and the spread of Plasmodium falciparum quintuple-mutant parasites resistant to sulfadoxine-pyrimethamine: a modelling study.

The Lancet. Microbe - 1 Sept 2024

Masserey Thiery, Lee Tamsin, Kelly Sherrie L, Hastings Ian M, Penny Melissa A

Abstract excerpt

BACKGROUND: Seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine plus amodiaquine prevents millions of clinical malaria cases in children younger than 5 years in Africa's Sahel region. However, Plasmodium falciparum parasites partially resistant to sulfadoxine-pyrimethamine (with quintuple mutations) potentially threaten the protective effectiveness of SMC. We evaluated the spread of...

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PMID: 38996497
DOI: 10.1016/S2666-5247(24)00115-0

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