Article
Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression.
The Journal of biological chemistry - 18 Oct 2002
Guaita Sandra, Puig Isabel, Franci Clara, Garrido Marta, Dominguez David, Batlle Eduard, Sancho Elena, Dedhar Shoukat, De Herreros Antonio Garcia, Baulida Josep
Abstract excerpt
E-cadherin protein plays a key role in the establishment and maintenance of adherent junctions. Recent evidence implicates the transcription factor Snail in the blockage of E-cadherin expression in fibroblasts and some epithelial tumor cells through direct binding to three E-boxes in the E-cadherin promoter. Transfection of Snail into epithelial cells leads to a more fibroblastic phenotype. Cells expressing Snail...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.