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Article

Association between acquired uniparental disomy and homozygous gene mutation in acute myeloid leukemias.

Cancer research - 15 Oct 2005

Fitzgibbon Jude, Smith Lan-Lan, Raghavan Manoj, Smith Matthew L, Debernardi Silvana, Skoulakis Spyros, Lillington Debra, Lister T Andrew, Young Bryan D

Abstract excerpt

Genome-wide single nucleotide polymorphism analysis has revealed large-scale cryptic regions of acquired homozygosity in the form of segmental uniparental disomy in approximately 20% of acute myeloid leukemias. We have investigated whether such regions, which are the consequence of mitotic recombination, contain homozygous mutations in genes known to be mutational targets in leukemia. In 7 of 13 cases with...

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Source

Identifiers

PMID: 16230371
DOI: 10.1158/0008-5472.CAN-05-2017

Genes

FLT3
JAK2
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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