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Article

Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia.

Blood - 1 Aug 2008

Raghavan Manoj, Smith Lan-Lan, Lillington Debra M, Chaplin Tracy, Kakkas Ioannis, Molloy Gael, Chelala Claude, Cazier Jean-Baptiste, Cavenagh James D, Fitzgibbon Jude, Lister T Andrew, Young Bryan D

Abstract excerpt

Despite advances in the curative treatment of acute myeloid leukemia (AML), recurrence will occur in the majority of cases. At diagnosis, acquisition of segmental uniparental disomy (UPD) by mitotic recombination has been reported in 15% to 20% of AML cases, associated with homozygous mutations in the region of loss of heterozygosity. This study aimed to discover if clonal evolution from heterozygous to...

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Source

Identifiers

PMID: 18490517
DOI: 10.1182/blood-2008-01-132431

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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