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Article

Association between acquired uniparental disomy and homozygous mutations and HER2/ER/PR status in breast cancer.

PloS one - 30 Nov 2010

Tuna Musaffe, Smid Marcel, Zhu Dakai, Martens John W M, Amos Christopher I

Abstract excerpt

BACKGROUND: Genetic alterations in cellular signaling networks are a hallmark of cancer, however, effective methods to discover them are lacking. A novel form of abnormality called acquired uniparental disomy (aUPD) was recently found to pinpoint the region of mutated genes in various cancers, thereby identifying the region for next-generation sequencing. METHODS/PRINCIPAL FINDINGS: We retrieved large genomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21152100
DOI: 10.1371/journal.pone.0015094
PMCID: PMC2994899

Genes

CASP1
CASP4
CASP5
GRM7
MTAP
NFIB
SUMF1
VEZF1
WNT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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