Article
Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation.
Blood - 5 Mar 2009
O'Shea Derville, O'Riain Ciarán, Gupta Manu, Waters Rachel, Yang Youwen, Wrench David, Gribben John, Rosenwald Andreas, Ott German, Rimsza Lisa M, Holte Harald, Cazier Jean-Baptiste, Johnson Nathalie A, Campo Elias, Chan Wing C, Gascoyne Randy D, Young Bryan D, Staudt Louis M, Lister T Andrew, Fitzgibbon Jude
Abstract excerpt
Acquired homozygosity in the form of segmental acquired uniparental disomy (aUPD) has been described in follicular lymphoma (FL) and is usually due to mitotic recombination. SNP array analysis was performed with the use of the Affymetrix 10K 2.0 Gene-chip array on DNA from 185 diagnostic FL patients to assess the prognostic relevance of aUPD. Genetic abnormalities were detected in 118 (65%) of 182 patients....
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