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Article

Genomic DNA levels of mutant alpha-synuclein correlate with non-motor symptoms in an A53T Parkinson's disease mouse model.

Neurochemistry international - 1 Mar 2018

Wang Weiwei, Song Ning, Jia Fengjv, Tang Tingting, Bao Weiqi, Zuo Chuantao, Xie Junxia, Jiang Hong

Abstract excerpt

Alpha-synuclein plays a key role in the pathogenesis of Parkinson's disease (PD). A robust transgenic mouse model has been generated that overexpresses the mutant human A53T alpha-synuclein under the mouse prion protein gene promoter; these mice develop age-dependent motor deficits. Recently, compared to wild-type (WT) littermates, A53T alpha-synuclein mice were reported to display non-motor symptom deficits,...

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PMID: 29355568
DOI: 10.1016/j.neuint.2018.01.006

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