Article
Detection of minor populations of drug-resistant HIV-1 in acute seroconverters.
AIDS (London, England) - 4 Nov 2005
Metzner Karin J, Rauch Pia, Walter Hauke, Boesecke Christoph, Zöllner Bernhard, Jessen Heiko, Schewe Knud, Fenske Stefan, Gellermann Holger, Stellbrink Hans-Jürgen
Abstract excerpt
OBJECTIVE: The transmission of drug-resistant HIV-1 is a major health concern. To date, most clinical studies have relied on sequencing techniques for genotypic analyses which do not allow quantification of minority viral populations below 25%. As minor populations of drug-resistant HIV-1 could impact the efficiency of antiretroviral therapy, this study was performed to determine the prevalence of minor...
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